GV has been reported to be effective against Candida albicans and Gram-positive bacteria, particularly Staphylococcus sp , due to its ability to penetrate the bacterial cell wall. A systemic literature review also suggested that GV could be used to eradicate or disrupt biofilms in ear, nose, and throat ENT infections.
In June , Health Canada issued a safety alert on the potential risk of carcinogenicity with GV-containing products. In Canada, GV-containing products have been reported to be used on skin, mucous membranes e. Although Health Canada did not receive any cancer reports with the use of GV products, the agency highlighted its concerns over the potential oral exposure in infants as it had received adverse event reports non-cancer associated with the use of GV for oral thrush in two infants aged two and five months.
In response, the manufacturer of the only registered GV product Gentiane Violet Liquid Topical voluntarily discontinued the sale of the product in Canada. HSA has reviewed the available scientific literature and noted that current evidence on the carcinogenicity of GV has mainly been observed with high-dose oral exposure to GV in animal studies.
Tumours were observed in various organs e. They are all sterile dressings made of polyurethane foam, and are used for wounds such as sores, skin graft sites, abrasions and cuts. They are all made by one manufacturer Hydrofera.
These products do not pose an increased risk of cancer when used for a short time and in most people. The Department has requested that the manufacturer update the product labels to state that these products should not be used for longer than six months and should not be used by pregnant or nursing women as a precaution because of the lack of information available to support these uses.
Should the Department identify unauthorized health products containing gentian violet being sold in Canada, it will take appropriate and timely action to protect the health and safety of Canadians. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
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Furthermore, there are data showing that gentian violet can alter genetic material and cause cancer. Its use in cosmetic products has been banned by the French medicines agency. Nipple thrush is often over-diagnosed.
For proven cases of nipple thrush, or oral thrush in the newborn baby, antifungal drugs have been better studied than gentian violet, and can be used either as oral suspensions of nystatin or amphotericin B from birth, or from the age of 4 months, as a miconazole-based oral gel.
Source: "Gentian violet when breastfeeding: irritant and carcinogenic" Prescrire International ; 29 : Subscribers only. Enjoy full access to Prescrire International, and support independent information.
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